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The Effect of Corticosteroids for Acute Optic Neuritis on the Subsequent Development of Multiple Sclerosis NEJM 329:1764-1769, 1808-18101993., Beck,R.W.,et al, 1993 See this aricle in Pubmed Article Abstract Definite multiple sclerosis developed within the first two years in 7.5 percent of the intravenous-methyl-prednisolone group(134 patients),14.7 percent of the oral-prednisone group(129 patients),and 126.7 percent of the placebo group(126 patients).The adjusted rate ratio for the development of definite multiple sclerosis within two years in the intravenous-methylprednisolone group was 0.34)95 percent confidence interval,0.16 to 0.74)as compared with the placebo group and 0.38(95 percent confidence interval,0.17 to 0.83)as compared with the oral- prednisone group.The beneficial effect of the intravenous-steroid regimen appeared to lessen after the first two years of follow-up.Signal abnormalities on magnetic resonance imaging(MRI)of the brain were a strong indication of risk for the development of definite multiple sclerosis (adjusted rate ratio in patients with three or more lesions,5.53;95 percent confidence interval,2.41 to 12.66).The beneficial effect of treatment was most apparent in patients with abnormal MRI scans at entry. In patients with acute optic neuritis,treatment with a three-day course of high-dose intravenous methylprednisolone(followed by a short course of prednisone)reduces the rate of development of multiple sclerosis over a two-year period.

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(click to filter results - removes previous filter) multiple sclerosis optic neuritis optic neuritis,treatment of steroid steroid therapy,CNS treatment and complications with treatment of neurologic disorder

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